Paper title: ON MODELLING AND CONTROL OF A CLASS OF TUMOUR GROWTH PROCESSES
Author(s): VIRGINIA ECATERINA OLTEAN, RADU DOBRESCU, LORETTA ICHIM,
Abstract: Hybrid models based on state space quantisation and providing a nondeterministic
nature are a convenient framework for the study of behaviour prediction and control of
various complex biological processes with incomplete knowledge. Starting from a
model of a tumour growth process, in the literature, the paper proposes an abstract
quasi-random invasion process in a partitioned state space with a lattice structure. The
invader is a relative nutrient concentration. An event occurs whenever the numerical
gradient of the invader in an occupied cell reaches a threshold limit, thus allowing the
growth process to randomly occupy a new adjacent cell or position in the lattice.
Simulations of the system are performed, for different scenarios and a control
mechanism of the growth process is also proposed, incorporating feedback and
exogenous nutrient inhibitors.
Keywords: Complex systems, Hybrid systems, State space partition, Biological
modelling, Difference equation, Simulation Year: 2011 | Tome: 56 | Issue: 1 | Pp.: 109-118
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